Graduating from ALRA in 2003, Denise made her television debut in Casualty and has since appeared in many popular series from New Tricks to Stella.
Denise was nominated for The Milton Shulman Award for Outstanding Newcomer (2012), at the Evening Standard Theatre Awards for her performances in Eugene O'Neill's Desire Under the Elms at the Lyric Hammersmith and Nancy Harris's Our New Girl at the Bush Theatre.
She appeared as Julia in The Duchess of Malfi, the inaugural production at the Sam Wanamaker Playhouse in London.
In 2015, she debuted at the National Theatre in London, in Duncan Macmillan's People, Places and Things, directed by Jeremy Herrin. For this role, she won an Oliver Award for Best Leading Actress (2016). Denise was nominated in this category alongside Hollywood star Nicole Kidman.
She is going to return to the National Theatre in April 2017 playing the role of Harper in Marianne Elliot's revival of Tony Kushner's seminal play Angels in America, before returning to People, Places & Things for its New York transfer.
She's an active feminist and supporter of the ERA (Equal Representation for Actresses) campaign, which aims for a 50:50 gender split in casting.
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